:root {
  --navy: #075683;
  --navy-deep: #073d5d;
  --ink: #173645;
  --muted: #60747e;
  --teal: #42b5c4;
  --teal-deep: #099bab;
  --teal-soft: #e8f7f9;
  --orange: #f7941d;
  --orange-deep: #dd7d08;
  --cream: #fff0d6;
  --sand: #f5efe4;
  --gold: #b99d4f;
  --gray: #5e6870;
  --paper: #ffffff;
  --page: #ddf5ff;
  --line: #d9e8ea;
  --shadow: 0 24px 68px rgba(7, 61, 93, .115);
  --shadow-soft: 0 12px 30px rgba(7, 61, 93, .075);
  --radius-xl: 36px;
  --radius-lg: 26px;
  --radius-md: 18px;
  --shell: 1180px;
  --ease-out: cubic-bezier(.2, .75, .25, 1);
  --display: "Inter Tight", "Helvetica Neue", Arial, sans-serif;
  --body: "Inter Tight", "Helvetica Neue", Arial, sans-serif;
}

*, *::before, *::after {
  box-sizing: border-box;
}

html {
  overflow-x: clip;
  scroll-behavior: smooth;
  scroll-padding-top: 100px;
}

body {
  margin: 0;
  overflow-x: clip;
  color: var(--ink) !important;
  background-color: var(--page) !important;
  font-family: var(--body) !important;
  font-size: 17px !important;
  font-weight: 400 !important;
  line-height: 1.56;
  letter-spacing: -0.006em;
  font-optical-sizing: auto;
  font-synthesis: none;
  font-kerning: normal;
  text-rendering: optimizeLegibility;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}

@supports not (overflow: clip) {
  html, body {
    overflow-x: hidden;
  }
}
img, svg {
  display: block;
  max-width: 100%;
}

img {
  width: 100%;
  height: auto;
}

a {
  color: inherit;
}

button {
  font: inherit;
}

h1, h2, h3, h4 {
  text-wrap: balance;
}

p, li, figcaption {
  text-wrap: pretty;
}

::selection {
  background: rgba(247, 148, 29, 0.28);
  color: var(--navy-deep);
}

.shell {
  width: min(var(--shell), 100% - 48px);
  margin-inline: auto;
  padding: 0 1rem;
}

.section {
  position: relative;
}

.section-ribbon {
  background: var(--navy-deep);
  color: white;
}
.section-ribbon__inner {
  padding: 1rem;
}
.section-ribbon span {
  font: 700 18px/1.1 var(--display);
  letter-spacing: 0.035em;
  text-transform: uppercase;
}

.title-h1 {
  color: var(--navy);
  font-family: var(--display);
  font-weight: 700;
  font-size: clamp(36px, 3.8vw, 52px);
  line-height: 1.02;
  letter-spacing: -0.012em;
}

.title-h2 {
  color: var(--navy);
  font-family: var(--display);
  font-weight: 700;
  font-size: clamp(34px, 3.7vw, 50px);
  line-height: 1.02;
  letter-spacing: -0.012em;
}

.title-h3 {
  color: var(--navy);
  font-family: var(--display);
  font-weight: 700;
  font-size: clamp(22px, 4.3vw, 30px);
  line-height: 1.02;
  letter-spacing: -0.012em;
}

.text {
  color: #385460;
  font-size: 1.2rem;
  line-height: 1.5;
}

.sr-only {
  position: absolute !important;
  width: 1px;
  height: 1px;
  padding: 0;
  margin: -1px;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
  white-space: nowrap;
  border: 0;
}

.skip-link {
  position: fixed;
  z-index: 1000;
  left: 16px;
  top: 16px;
  transform: translateY(-160%);
  padding: 10px 16px;
  border-radius: 8px;
  background: var(--navy-deep);
  color: white;
  text-decoration: none;
  transition: transform 0.2s var(--ease-out);
}

.skip-link:focus {
  transform: translateY(0);
}

.eyebrow {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  color: var(--teal-deep);
  font-size: 14px;
  font-weight: 700;
  margin: 0;
  text-transform: uppercase;
  letter-spacing: 0.075em;
}

.micro-label {
  font-size: 14px;
  font-weight: 600;
  text-transform: none;
  font-style: italic;
}

.hero__grid {
  display: grid;
  grid-template-columns: minmax(0, 1.18fr) minmax(330px, 0.82fr);
  grid-template-areas: "heading visual" "heading visual";
  align-items: center;
  column-gap: 38px;
  row-gap: 12px;
}
.hero__heading {
  position: relative;
  z-index: 2;
  grid-area: heading;
  align-self: center;
}
.hero__heading h1 {
  max-width: 720px;
}
.hero__visual {
  position: relative;
  z-index: 2;
  grid-area: visual;
  display: grid;
  place-items: center;
}
.hero__visual img {
  border-radius: 30px;
}
.hero__image-wrap {
  position: relative;
  z-index: 2;
  width: min(100%, 450px);
  filter: drop-shadow(0 22px 50px rgba(7, 61, 93, 0.13));
}
.hero__meta {
  position: relative;
  z-index: 2;
  grid-area: meta;
  align-self: start;
}
.hero__authors {
  margin: 0 0 8px;
  color: var(--muted);
  font-size: 15.5px;
  line-height: 1.42;
}
.hero__authors strong {
  color: var(--ink);
}
.hero__authors .doi-link {
  display: inline;
  align-items: center;
  gap: 8px;
  color: var(--navy);
  font-size: inherit;
  font-weight: 700;
  text-underline-offset: 3px;
}
.hero__edition {
  margin: 20px 0 0;
  padding-left: 15px;
  border-left: 3px solid var(--teal);
  color: var(--muted);
  font-size: 14px;
}

.information {
  font-size: 0.8rem !important;
}
.information__wrapper {
  padding: 0.8rem;
  background-color: white;
  border-radius: 4px;
  filter: drop-shadow(0 4px 4px rgba(0, 0, 0, 0.15));
}
.information__wrapper .text {
  font-size: 0.8rem !important;
}
.information__grid {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  place-items: center;
  gap: 1.2rem;
  padding: 1.2rem;
  border-radius: var(--radius-lg);
  background-color: #F1EADF;
}
.information__grid .item-full {
  grid-column: span 2;
}
.information__list {
  list-style: disc;
  padding-top: 0.8rem;
  padding-left: 28px;
}
.information__list li {
  margin-bottom: 0.6rem;
}
.information__table {
  width: 100%;
  border: 1px solid var(--teal);
}
.information__table thead {
  background-color: #cceaff;
}
.information__table tr {
  transition: background-color 0.5s ease;
}
.information__table tr:hover {
  cursor: pointer;
  background-color: rgba(66, 181, 196, 0.2) !important;
}
.information__table tr:not(:last-child), .information__table tr:first-child {
  border-bottom: 1px solid var(--teal);
}
.information__table .border-desc {
  border-bottom: 3px solid var(--teal) !important;
}
.information__table th, .information__table td {
  padding: 0.2rem;
  text-align: center;
}
.information__table th, .information__table td {
  border-right: 1px solid var(--teal);
}

.clinics__grid {
  display: grid;
  grid-template-columns: 2fr 1fr;
  place-items: start;
  gap: 0;
}
.clinics__grid img {
  max-width: 420px;
  margin-left: -40px;
}

.results__grid {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 16px;
}
.results__card {
  position: relative;
  padding: 18px 32px;
  overflow: hidden;
  border-radius: var(--radius-lg);
  display: flex;
  flex-direction: column;
  justify-content: center;
  transition: transform 0.24s var(--ease-out), box-shadow 0.24s ease, border-color 0.24s ease;
  box-shadow: 2px 2px 4px 2px rgba(0, 0, 0, 0.06);
}
.results__card:hover {
  transform: translateY(-2px);
  box-shadow: var(--shadow);
}
.results__card span {
  position: relative;
  z-index: 2;
  max-width: 270px;
  margin-top: 14px;
  color: var(--ink);
  font-size: 15px;
  line-height: 1.35;
}
.results__card--cream {
  background: var(--cream);
}
.results__card--cream strong {
  position: relative;
  z-index: 2;
  color: var(--orange);
  font: 800 clamp(38px, 4vw, 56px)/0.92 var(--display);
  letter-spacing: -0.024em;
}
.results__card--blue {
  background: #dff4f7;
}
.results__card--blue strong {
  position: relative;
  z-index: 2;
  font: 800 clamp(38px, 4vw, 56px)/0.92 var(--display);
  letter-spacing: -0.024em;
  color: var(--teal-deep);
}
.results__card--ring-cream {
  position: absolute;
  width: 150px;
  aspect-ratio: 1;
  right: -34px;
  top: -45px;
  border-radius: 50%;
  border: 27px solid rgba(247, 148, 29, 0.12);
}
.results__card--ring-blue {
  position: absolute;
  width: 150px;
  aspect-ratio: 1;
  right: -34px;
  top: -45px;
  border-radius: 50%;
  border: 27px solid rgba(66, 181, 196, 0.19);
}

.medical-footer {
  background: white;
}
.medical-footer .litra {
  border-bottom: 1px solid var(--teal-deep);
  font-size: 14px;
  font-weight: 400;
  overflow-wrap: break-word;
}
.medical-footer__code {
  margin: 0;
  padding: 0 0 5px;
  border-bottom: 1px solid var(--teal-deep);
  color: #263b45;
  font-size: 13px;
  line-height: 1.5;
}
.medical-footer__fine {
  margin: 6px 0 0;
  color: #5d6265;
  font-size: 11px;
  line-height: 1.28;
}
.medical-footer__bottom {
  margin: 4px 0 0;
  padding: 0;
  display: block;
  border: 0;
  color: #666;
  font-size: 1.5rem;
  font-weight: 700;
  line-height: 1.35;
  text-align: center;
  text-transform: uppercase;
}
.medical-footer .bad-info {
  font-size: clamp(1.5rem, 0.8519rem + 5.1852vw, 4rem);
  color: var(--color-text-1);
  font-weight: 100;
  margin: 24px 0;
  text-align: center;
}

.lead-card {
  position: relative;
  z-index: 3;
  padding: 31px 36px;
  display: grid;
  grid-template-columns: 64px 1fr;
  gap: 24px;
  align-items: start;
  border-radius: 8px var(--radius-lg) var(--radius-lg) 8px;
  background: var(--paper);
  box-shadow: var(--shadow-soft);
  border: 1px solid rgba(7, 86, 131, 0.07);
}
.lead-card::before {
  content: "";
  position: absolute;
  inset: 0 auto 0 0;
  width: 6px;
  border-radius: var(--radius-lg) 0 0 var(--radius-lg);
  background-color: var(--orange);
}
.lead-card__icon {
  width: 64px;
  height: 64px;
  display: grid;
  place-items: center;
  border-radius: 50%;
  background: var(--teal-soft);
}
.lead-card__icon svg {
  width: 40px;
  height: 40px;
  fill: none;
  stroke: var(--navy);
  stroke-width: 2.3;
}
.lead-card p, .lead-card li {
  margin: 0;
  color: #354f5c;
  font-size: 18px;
  line-height: 1.58;
}
.lead-card.no-icon {
  display: block;
}

.lead-card.navy::before {
  background-color: var(--navy);
}

.lead-card.teal::before {
  background-color: var(--teal-deep);
}

.figure-button {
  position: relative;
  width: 100%;
  padding: 0;
  overflow: hidden;
  border-radius: var(--radius-lg);
  border: 0;
  background: #DDF5FF;
  cursor: zoom-in;
  box-shadow: var(--shadow-soft);
}
.figure-button:hover img {
  transform: scale(1.012);
}
.figure-button img {
  width: 100%;
  height: auto;
  transition: transform 0.32s var(--ease-out);
}

.image-dialog {
  max-width: min(1260px, 100vw - 40px);
  max-height: calc(100vh - 40px);
  padding: 0;
  overflow: visible;
  border: 0;
  border-radius: 20px;
  background: #DDF5FF;
  box-shadow: 0 40px 100px rgba(0, 0, 0, 0.4);
  margin: auto;
}
.image-dialog:not([open]) {
  display: none !important;
}
.image-dialog::backdrop {
  background: rgba(2, 25, 38, 0.82);
  backdrop-filter: blur(8px);
}
.image-dialog img {
  max-width: calc(100vw - 40px);
  max-height: calc(100vh - 40px);
  width: 100%;
  height: auto;
  border-radius: 20px;
}
.image-dialog__close {
  position: absolute;
  z-index: 2;
  right: -14px;
  top: -14px;
  width: 42px;
  height: 42px;
  border: 2px solid white;
  border-radius: 50%;
  background: var(--navy-deep);
  color: white;
  font-size: 28px;
  line-height: 1;
  cursor: pointer;
}
.image-dialog__close svg {
  width: 21px;
  height: 21px;
  margin: auto;
  fill: none;
  stroke: currentColor;
  stroke-width: 2.2;
  stroke-linecap: round;
}

@media (max-width: 991px) {
  .information__grid {
    grid-template-columns: 1fr;
  }
  .information__grid .item-full {
    grid-column: span 1;
  }
}
@media (max-width: 820px) {
  html {
    font-size: 14px;
  }
  .hero__grid {
    grid-template-columns: 1fr;
    grid-template-areas: "heading" "visual" "meta";
    row-gap: 20px;
  }
  .lead-card {
    grid-template-columns: 1fr;
    gap: 15px;
    padding: 27px 27px 27px 31px;
  }
  .lead-card p {
    font-size: 16px;
  }
  .clinics__grid {
    display: grid;
    grid-template-columns: 1fr;
    place-items: center;
    gap: 0;
  }
  .clinics__grid img {
    max-width: 400px;
    margin-left: 0;
    margin-bottom: -60px;
    order: 1;
  }
  .clinics__grid .lead-card {
    order: 2;
  }
}
@media (max-width: 767px) {
  .information table, .information thead, .information tbody, .information tr, .information th, .information td {
    display: block;
    width: 100%;
  }
  .information th, .information td {
    border-right: none;
  }
}
@media (max-width: 580px) {
  html {
    font-size: 12px;
  }
  .lead-card__icon {
    width: 54px;
    height: 54px;
  }
  .results__grid {
    grid-template-columns: repeat(1, 1fr);
  }
}

/*# sourceMappingURL=styles.css.map */