Исследования и практика в медицине №03 2021
О механизмах противоопухолевого действия соединений трополонового ряда
Номера страниц в выпуске:118-132
В обзоре приведены сведения о механизмах противоопухолевого действия природных и синтетических соединений трополонового ряда, полученные в течение последних 30 лет в исследованиях на культурах клеток и, в меньшей степени, в экспериментах in vivo. Интерес к данной группе веществ обусловлен острой потребностью клинической онкологии в средствах, эффективно повреждающих злокачественные клетки и, одновременно, безопасных для здоровых тканей. Наиболее полно изучены процессы, реализующие эффекты колхицина, хинокитиола (ß-туйяплицина) и некоторых их дериватов (производные бистрополона, α-замещенные трополоны и др). При этом были выявлены более многочисленные механизмы реализации противоопухолевого действия хинокитиола и его производных по сравнению с колхицином. Помимо нарушения формирования веретена деления, показанного для колхицина и колхамина, описаны такие явления, как каспазо-зависимый апоптоз и некоторые другие виды апоптоза, аутофагия, ограничение митохондриального метаболизма, повреждение и деметилирование ДНК, ускоренное старение малигнизированных клеток и проч.
Показана перспективность использовавния производных 2‑хинолил 1,3‑трополона и связь их противоопухолевого действия с индукцией апоптоза и изменением активности сигнального пути ERK в некоторых типах малигнизированных клеток. Полученные результаты свидетельствуют о многообразии возможных путей влияния трополонов на состояние злокачественных клеток, условия реализации каждого из которых нуждаются в уточнении, особенно при дефиците сведений о процессах in vivo.
В обзоре использованы сведения литературы, представленной в базах данных Scopus, WoS, Pubmed. 35 % работ опубликовано за последние 5 лет.
В обзоре использованы сведения литературы, представленной в базах данных Scopus, WoS, Pubmed. 35 % работ опубликовано за последние 5 лет.
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