Тромбоз, гемостаз и реология №02 2015

Значение инфекции и воспаления в развитии атеросклероза. Диагностика и лечение

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Инфекция и воспаление играют ведущую роль в индукции и прогрессировании атеросклероза. Инфекция способствует процессу атерогенеза и развитию осложнений атеросклероза, вызванных разрывом атеросклеротической бляшки. Уязвимые атеросклеротические бляшки имеют признаки локального воспаления. Атеросклеротические бляшки с подобными особенностями могут разорваться и способствовать развитию тромбоза. Современные исследования показывают целесообразность противоспалительной терапии для достижения стабильности атеросклеротической бляшки. Разработка лабораторной и неинвазивной инструментальной диагностики и новых противоспалительных терапевтических подходов для предотвращения атеротромбоза является важным приоритетом исследований в сердечно-сосудистой сфере.

Инфекция и воспаление играют ведущую роль в индукции и прогрессировании атеросклероза. Инфекция способствует процессу атерогенеза и развитию осложнений атеросклероза, вызванных разрывом атеросклеротической бляшки. Уязвимые атеросклеротические бляшки имеют признаки локального воспаления. Атеросклеротические бляшки с подобными особенностями могут разорваться и способствовать развитию тромбоза.

Современные исследования показывают целесообразность противоспалительной терапии для достижения стабильности атеросклеротической бляшки. Разработка лабораторной и неинвазивной инструментальной диагностики и новых противоспалительных терапевтических подходов для предотвращения атеротромбоза является важным приоритетом исследований в сердечно-сосудистой сфере.

Ключевые слова: атеросклероз — диагностика и лечение — воспаление — инфекционные заболевания.

Для корреспонденции

Аршинов Андрей Владимирович — д.м.н., профессор кафедры пропедевтики внутренних болезней ГБОУ ВПО ЯГМА МЗ РФ.

Адрес: 150000, Россия, Ярославль, ул. Революционная, д. 5.

E-mail: a_arshinov@mail.ru

Статья поступила 27.03.2014, принята к печати 30.01.2015.

IMPORTANCE OF INFECTION AND INFLAMMATION IN ATHEROSCLEROSIS DEVELOPMENT. DIAGNOSTICS AND TREATMENT

A. V. Arshinov, Yu.A. Goncharova, I. G. Maslova

Yaroslavl State Medical Academy, Health Ministry of Russian Federation, Yaroslavl, Russia

Yaroslavl State Medical Academy, Health Ministry of Russian Federation, Yaroslavl, Russia Infection and inflammation play the leading role in induction and progression of atherosclerosis. Infection promotes the development of atherogenesis and its complications caused by rupture of atherosclerotic plaque. Vulnerable atherosclerotic plaques have symptoms of local inflammation. Atherosclerotic plaques with such characteristics may rupture and promote thrombosis.

Current studies show appropriateness of anti-inflammatory therapy for achieving stability of atherosclerotic plaque. Elaboration of laboratory and noninvasive instrumental diagnostics and new anti-inflammatory therapeutic approaches for atherothrombosis prevention is important priority in cardiovascular researches.

Key words: atherosclerosis — diagnostics and treatment — inflammation — infectious diseases.

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