Psychiatry and psychopharmacotherapy №05 2016

 Psychiatry and psychopharmacotherapy №05 2016
About
The results of the analysis of clinical and psychopathological features used in the definitions of delusions. The necessity of allocation of general and specific, obligate and facultative signs of delusional ideas, allow to distinguish them from other variants of pathological ideas. Delusional disorders are seen as complex multi-states, including perceptual, ideational, affective, and behavioral components. We discuss the basic psychological mechanisms of delirium.
Key words: general psychopathology, delirium criteria, primary delusional experience.
V.I.Krylov.
4-9
For the first time the simulation of biological properties etifoxine (Stresam active principle of the drug). For this may molecule obtained reliable estimates of more than 2500 biological activities and a comparison with the control preparation – lorazepam (benzodiazepine). Hemoreaktomic simulation results suggest significant differences etifoxine between pharmacological effects and investigated benzodiazepine in: 1) receptor binding selectivity of various neurotransmitters; 2) anti-inflammatory effect; 3) action on hemodynamics and the condition of the vessel walls; 4) the presence of side effects; 5) pharmacokinetic parameters. The results correspond to the available experimental and clinical data, and point to promising eg etifoxine board of therapeutic applications.
Key words: hemoreaktomic analysis, bioinformatics, etifoxine.
I.Yu.Torshin1, O.A.Gromova2, L.E.Fedotova2, A.N.Gromov3.
10-17
1 Moscow Institute of Physics and Technology. 141700, Russian Federation, Dolgoprudnyi, Institutskii per., d. 9; 2 Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation. 153000, Russian Federation, Ivanovo, Sheremetevskii pr-t, d. 8; 3 Federal Research Centre "Information and Management". 119333, Russian Federation, Moscow, ul. Vavilova, d. 40
Here is a review and analysis of the effectiveness of different groups of antidepressants that have been premedicated to patients with schizophrenia with comorbid depressive symptoms. The aim of this work was to evaluate the efficacy of Valdoxan in combination with antipsychotic therapy in the treatment of schizophrenic patients with comorbid depressive symptoms. This research included 20 patients with paranoid schizophrenia, with comorbid depressive symptoms. The result shows a clear positive trend for the reduction of affective disorders. The treatment that combine therapy Valdoxan (agomelatine) and neuroleptics was effective. These results show the possibility of combined use of these drugs in the treatment of affective disorders as a part of schizophrenia structure.
Key words: neurocognitive deficits in schizophrenia patients, Valdoxan.
A.G.Sofronov1, A.A.Spikina1, O.V.Rylskaia2.
18-24
1 I.I.Mechnikov State Northwestern Medical University of the Ministry of Health of the Russian Federation. 191015, Russian Federation, Saint Petersburg, ul. Kirochnaia, d. 41; 2 Psychoneurological State Dispensary №9 192131, Russian Federation, Saint Petersburg, ul. Ivanovskaia, d. 18
Sulpiride is an atypical antipsychotic with distinctive pharmacological properties, among which are 5-HT4 partial agonism, GHB partial agonism, D2/D3 dopaminergic antagonism with preferential presynaptic D2/D3 blockade at low doses and preferential extrastriatal postsynaptic D2 blockade at high doses. These unique properties make sulpiride at low doses an effective antidepressant, anxiolytic and antipanic medication, while at high doses it behaves like an atypical antipsychotic with low overall side effect burden (no anticholinergic, no adrenergic, no histaminergic side effects) and low propensity to cause EPS. Here we review the relevant literature on its efficacy in different anxiety disorders.
Key words: sulpiride, anxiety disorders, specific phobias, generalized anxiety disorder, panic disorder, posttraumatic stress disorder, psychosomatic disorders, migraine, pain disorders.
Yu.V.Bykov1, R.A.Bekker2.
25-33
1 Stavropol State Medical University of the Ministry of Health of the Russian Federation. 355017, Russian Federation, Stavropol, ul. Mira, d. 310; 2 David Ben-Gurion University in Negev. 8410501, Israel, Be'er-Sheva
An open clinical trial of fluvoxamine influence on depression and neurocognitive deficits in 100 schizophrenia patients aged 18–45 years was conducted. Depression was verified by Calgary scale. Neurocognitive deficit was assessed by using standard valid psychological tests. Results show significant improvement of cognitive functions in schizophrenia patients. Fluvoxamine can be recommended as a drug for possible improvement of neurocognitive deficits. Fluvoxamine can be used in standard dosages.
Key words: neurocognitive deficits in schizophrenia patients, fluvoxamine.
A.G.Sofronov, A.P.Savelyev, A.A.Spikina.
34-37
I.I.Mechnikov State Northwestern Medical University of the Ministry of Health of the Russian Federation. 191015, Russian Federation, Saint Petersburg, ul. Kirochnaia, d. 41.
The article outlines the key problems of child psychiatry, which are considered from the perspective of the traditions of the Russian school of psychiatry in relation to the trends generated mainly American psychiatry. Denotes the inconsistency diagnostic approaches and, accordingly, often a tendency to expand the number of diagnoses of psychopathological conditions in childhood (mainly at the level of the syndrome) with excessive inclusion of patients in the pharmacotherapy.
Key words: child psychiatry, psychopharmacology.
V.G.Budza1, E.Yu.Antokhin1, E.M.Kryukova2, S.V.Palyaeva2, R.I.Palaeva1.
38-41
1 Orenburg State Medical University of the Ministry of Health of the Russian Federation. 460000, Russian Federation, Orenburg, ul. Sovetskaia, d. 6; 2 Orenburg Regional Clinical Psychiatric Hospital №1. 460006, Russian Federation, Orenburg, ul. Tsvillinga, d. 5.
Scientists showed interest to play activity from the earliest times, but the systematic study of the phenomenon of the play started from the late XIX-th century. Age dynamics of play activity adheres to a certain stage of ontogenesis. Play activity of children with mental disabilities may have a number of features. In our study, we examined children with autism spectrum disorders of various origins, found a number of features and differences in play activities of a group of children with schizophrenia disorders, from play activity of children with early childhood autism. This study is aimed at solving the main problems of child psychiatry, searching for clinical and psychological criteria of early diagnosis of autism spectrum disorders by features of play activity in early childhood and preschool age.
Key words: play, play activity, autism, early diagnosis, child psychiatry.
S.A.Voskresenskaya, G.V.Kozlovskaya, N.V.Simashkova, N.I.Golubeva, M.V.Ivanov.
42-47
Mental Health Research Center. 115522, Russian Federation, Moscow, Kashirskoe sh., d. 34
The urgency of the problem of borderline psychic disorders on the level of sick men with somatic pathology including diseases of cardiovascular system increases from year to year. The results of numerous studies testify to the effect of high frequency (50–60%) and of considerable evidence of psychic disorders with somatic patients. The article presents the main dispositions concerning the particularities of appearing, early diagnosis, developments of psychic disorders with the patients suffering from diseases of cardiovascular system, it reflects the mechanism of not psychotic disorders with the patients in a cardiac stationary hospital. It also exposes the principles of treatment considering modern scientific and practical achievements.
Key words: psychic disorders, diseases of cardiovascular system, not psychotic disorders, depression, myocardial infarction, stenocardia, "cardiogenic" psychosis.
L.A.Podrezova, A.N.Bogdan, Yu.V.Seyku, L.A.Krasnoslobodtseva, E.M.Mutnykh.
48-51
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
One of the most actualtheme presented on 24 EPA Congress was child psychiatry. The most significant reports were dedicated to the restructuring of psychiatric care provided in Europe and the characteristics of the formation of mental disorders in children psychological trauma.
Key words: mental disorders of childhood, succession, trauma, personality disorder.
P.V.Krasnovа.
52-54
Center for Psychological and Psychiatric correction and rehabilitation "Person". 050050, Kazakhstan, Almaty, b-r Bukhar Zhyrau, d. 75