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1Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences University of California, Los Angeles (UCLA) Los Angeles CA USA; 2Desert Pacific Mental Illness Research, Education and Clinical Center Veterans Affairs Greater Los Angeles Healthcare System Los Angeles CA USA; 3Veterans Affairs Program for Enhancing Community Integration for Homeless Veterans Los Angeles CA USA
Список исп. литературыСкрыть список 1. Bleuler E. Dementia praecox, oder Gruppe der Schizophrenien. Leipzig: Deuticke, 1911. 2. Jaspers K. Allgemeine Psychopathologie. Berlin: Springer, 1913. 3. Kraepelin E. Psychiatrie: Ein Lehrbuch fur Studierende und Arzte, 8th ed Leipzig: Barth, 1913. 4. Zubin J. Symposium on statistics for the clinician. J Clin Psychol 1950;6:1-6. 5. Zubin J, Spring B. Vulnerability: a new view of schizophrenia. J Abnorm Psychol 1977;86: 103-26.858828 6. Shakow D. Segmental set. Arch Gen Psychiatry 1962;6:1-17.13911157 7. Johnstone EC, Crow TJ, Frith CD et al. Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet 1976;2:924-6.62160 8. Weinberger DR, Torrey EF, Neophytides AN et al. Lateral cerebral ventricular enlargement in chronic schizophrenia. Arch Gen Psychiatry 1979;36:735-9.36863 9. Berman KF, Zec RF, Weinberger DR. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. Arch Gen Psychiatry 1986;43:126-35.2868701 10. Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 1996;153:321-30.8610818 11. Green MF, Kern RS, Braff DL et al. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”? Schizophr Bull 2000;26:119-36.10755673 12. Green MF, Kern RS, Heaton RK. Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophr Res 2004;72:41-51.15531406 13. Goldberg TE, Greenberg RD, Griffin SJ et al. The effect of clozapine on cognition and psychiatric symptoms in patients with schizophrenia. Br J Psychiatry 1993;162:43-8.842 5138 14. Green MF, Marder SR, Glynn SM et al. The neurocognitive effects of low-dose haloperidol: a two-year comparison with risperidone. Biol Psychiatry 2002;51:972-8.12062881 15. Green MF. Cognitive remediation in schizophrenia: is it time yet? Am J Psychiatry 1993;150:178-87.8422068 16. Harvey PD, Keefe RSE. Studies of the cognitive change in patients with schizophrenia following novel antipsychotic treatment. Am J Psychiatry 2001;158:176-84.11156796 17. Nuechterlein KH, Dawson ME. Information processing and attentional functioning in the developmental course of schizophrenia disorders. Schizophr Bull 1984;10:160-203.6729409 18. Nuechterlein KH, Barch DM, Gold JM et al. Identification of separable cognitive factors in schizophrenia. Schizophr Res 2004;72:29-39.15531405 19. Javitt DC, Freedman R. Sensory processing dysfunction in the personal experience and neuronal machinery of schizophrenia. Am J Psychiatry 2015;172:17-31.25553496 20. Adolphs R. Social cognition and the human brain. Trends Cogn Sci 1999;3:469-79.10562726 21. Green MF, Olivier B, Crawley JN et al. Social cognition in schizophrenia: recommendations from the MATRICS New Approaches Conference. Schizophr Bull 2005;31:882-7.16135561 22. Green MF, Penn DL, Bentall R et al. Social cognition in schizophrenia: an NIMH workshop on definitions, assessment, and research opportunities. Schizophr Bull 2008;34:1211-20.18184635 23. Ochsner KN. The social-emotional processing stream: five core constructs and their translational potential for schizophrenia and beyond. Biol Psychiatry 2008;64:48-61.18549876 24. Nuechterlein KH, Robbins TW, Einat H. Distinguishing separable domains of cognition in human and animal studies: what separations are optimal for targeting interventions? A summary of recommendations from breakout group 2 at the measurement and treatment research to improve cognition in schizophrenia new approaches conference. Schizophr Bull 2005;31:870-4.16150960 25. Mesholam-Gately RI, Giuliano AJ, Goff KP et al. Neurocognition in first-episode schizophrenia: a meta-analytic review. Neuropsychology 2009;23:315-36.19413446 26. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 1998;12:426-45.9673998 27. Gold JM. Cognitive deficits as treatment targets in schizophrenia. Schizophr Res 2004;72:21-8.15531404 28. Seidman LJ, Mirsky AF. Evolving notions of schizophrenia as a developmental neurocognitive disorder. J Int Neuropsychol Soc 2017;23:881-92.29198285 29. Bora E, Lin A, Wood SJ et al. Cognitive deficits in youth with familial and clinical high risk to psychosis: a systematic review and meta-analysis. Acta Psychiatr Scand 2014;130:1-15.24611632 30. Savla GN, Vella L, Armstrong CC et al. Deficits in domains of social cognition in schizophrenia: a meta-analysis of the empirical evidence. Schizophr Bull 2013;39:979-92.22949733 31. Healey KM, Bartholomeusz CF, Penn DL. Deficits in social cognition in first episode psychosis: a review of the literature. Clin Psychol Rev 2016;50:108-37.27771557 32. McCleery A, Horan WP, Green MF. Social cognition during the early phase of schizophrenia In: P Lysaker, G Dimaggio, M Brune (eds). Metacognition and social cognition in schizophrenia. New York: Elsevier, 2014: 9-57. 33. Lee TY, Hong SB, Shin NY et al. Social cognitive functioning in prodromal psychosis: a meta-analysis. Schizophr Res 2015;164:28-34.25749019 34. Javitt DC. When doors of perception close: bottom-up models of disrupted cognition in schizophrenia. Annu Rev Clin Psychol 2009;5:249-75.19327031 35. Green MF, Lee J, Wynn JK et al. Visual masking in schizophrenia: overview and theoretical implications. Schizophr Bull 2011;37:700-8.21606322 36. Green MF, Nuechterlein KH, Mintz J. Backward masking in schizophrenia and mania: specifying a mechanism. Arch Gen Psychiatry 1994;51:939-44.7979881 37. Butler PB, Schechter I, Zemon V et al. Dysfunction of early-stage visual processing in schizophrenia. Am J Psychiatry 2001;158: 1126-33.11431235 38. Rund BR. Backward-masking performance in chronic and nonchronic schizophrenics, affectively disturbed patients, and normal control subjects. J Abnorm Psychol 1993;102:74-81.8436702 39. Sergi MJ, Rassovsky Y, Nuechterlein KH et al. Social perception as a mediator of the influence of early visual processing on functional status in schizophrenia. Am J Psychiatry 2006;163:448-54.16513866 40. Bedwell JS, Rassovsky Y, Orem DM et al. The backward masking red light effect in schizophrenia: relationship to clinical features and neurocognitive performance. J Abnorm Psychol 2011;120:490-6.212 80929 41. Leitman DI, Sehatpour P, Higgins BA et al. Sensory deficits and distributed hierarchical dysfunction in schizophrenia. Am J Psychiatry 2010;167:818-27.20478875 42. Umbricht DS, Bates JA, Lieberman JA et al. Electrophysiological indices of automatic and controlled auditory information processing in first-episode, recent-onset and chronic schizophrenia. Biol Psychiatry 2006;59:762-72.16497277 43. Erickson MA, Ruffle A, Gold JM. A meta-analysis of mismatch negativity in schizophrenia: from clinical risk to disease specificity and progression. Biol Psychiatry 2016;79:980-7.26444073 44. Naatanen R, Jiang D, Lavikainen J et al. Event-related potentials reveal a memory trace for temporal features. Neuroreport 1993;5:310-2.8298095 45. Kawakubo Y, Kasai K, Kudo N et al. Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia. Neuroreport 2006;17:1043-6.16791100 46. Wynn JK, Sugar C, Horan WP et al. Mismatch negativity, social cognition, and functioning in schizophrenia patients. Biol Psychiatry 2010;67:940-7.20074704 47. Light GA, Braff DL. Mismatch negativity deficits are associated with poor functioning in schizophrenia patients. Arch Gen Psychiatry 2005;62:127-36.15699289 48. Light GA, Swerdlow NR, Braff DL. Preattentive sensory processing as indexed by the MMN and P3a brain responses is associated with cognitive and psychosocial functioning in healthy adults. J Cogn Neurosci 2007;19:1624-32.18271737 49. Heaton R, Paulsen JS, McAdams LA et al. Neuropsychological deficits in schizophrenics: relationship to age, chronicity, and dementia. Arch Gen Psychiatry 1994;51: 469-76.8192549 50. Kazui H, Yoshida T, Takaya M et al. Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer’s disease in the mild cognitive impairment stage. Dement Geriatr Cogn Dis Extra 2011;1:20-30.22163230 51. Trotta A, Murray RM, MacCabe JH. Do premorbid and post-onset cognitive functioning differ between schizophrenia and bipolar disorder? A systematic review and meta-analysis. Psychol Med 2015;45:381-94.25065268 52. Bora E, Pantelis C. Meta-analysis of cognitive impairment in first-episode bipolar disorder: comparison with first-episode schizophrenia and healthy controls. Schizophr Bull 2015;41:1095-104.25616505 53. Bora E, Pantelis C. Social cognition in schizophrenia in comparison to bipolar disorder: a meta-analysis. Schizophr Res 2016;175:72-8.27117677 54. Bora E, Yucel M, Pantelis C. Cognitive impairment in affective psychoses: a meta-analysis. Schizophr Bull 2010;36:112-25.19767349 55. Sasson NJ, Pinkham AE, Weittenhiller LP et al. Context effects on facial affect recognition in schizophrenia and autism: behavioral and eye-tracking evidence. Schizophr Bull 2016;42:675-83.26645375 56. Eack SM, Wojtalik JA, Keshavan MS et al. Social-cognitive brain function and connectivity during visual perspective-taking in autism and schizophrenia. Schizophr Res 2017;183:102-9.28291690 57. Tobe RH, Corcoran CM, Breland M et al. Differential profiles in auditory social cognition deficits between adults with autism and schizophrenia spectrum disorders: a preliminary analysis. J Psychiatr Res 2016;79:21-7.27131617 58. Martinez G, Alexandre C, Mam-Lam-Fook C et al. Phenotypic continuum between autism and schizophrenia: evidence from the Movie for the Assessment of Social Cognition (MASC). Schizophr Res 2017;185:161-6.28089135 59. Zheng W, Zhang QE, Cai DB et al. Neurocognitive dysfunction in subjects at clinical high risk for psychosis: a meta-analysis. J Psychiatr Res 2018;103:38-45.29772485 60. Bora E, Murray RM. Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis: do the cognitive deficits progress over, or after, the onset of psychosis? Schizophr Bull 2014;40:744-55.23770934 61. Bora E, Yucel M, Pantelis C. Cognitive functioning in schizophrenia, schizoaffective disorder and affective psychoses: meta-analytic study. Br J Psychiatry 2009;195:475-82. 19949193 62. De Herdt A, Wampers M, Vancampfort D et al. Neurocognition in clinical high risk young adults who did or did not convert to a first schizophrenic psychosis: a meta-analysis. Schizophr Res 2013;149:48-55. 23830855 63. Rund BR, Barder HE, Evensen J et al. Neurocognition and duration of psychosis: a 10-year follow-up of first-episode patients. Schizophr Bull 2016;42:87-95.26101305 64. McCleery A, Lee J, Fiske AP et al. Longitudinal stability of social cognition in schizophrenia: a 5-year follow-up of social perception and emotion processing. Schizophr Res 2016;176:467-72.27443808 65. Friedman JI, Harvey PD, Coleman T et al. Six-year follow-up study of cognitive and functional status across the lifespan in schizophrenia: a comparison with Alzheimer’s disease and normal aging. Am J Psychiatry 2001;158:1441-8.11532729 66. Thompson WK, Savla GN, Vahia IV et al. Characterizing trajectories of cognitive functioning in older adults with schizophrenia: does method matter? Schizophr Res 2013;143:90-6.23218560 67. Crow TJ, Done DJ, Sacker A. Childhood precursors of psychosis as clues to its evolutionary origins. Eur Arch Psychiatry Clin Neurosci 1995;245:61-9.7654790 68. Jones P, Rodgers B, Murray R et al. Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet 1994;344:1398-402.7968076 69. Reichenberg A, Caspi A, Harrington H et al. Static and dynamic cognitive deficits in childhood preceding adult schizophrenia: a 30-year study. Am J Psychiatry 2010;167:160-9.20048021 70. MacCabe JH, Wicks S, Lofving S et al. Decline in cognitive performance between ages 13 and 18 years and the risk for psychosis in adulthood: a Swedish longitudinal cohort study in males. JAMA Psychiatry 2013;70:261-70.23325066 71. Hahn B, Robinson BM, Leonard CJ et al. Posterior parietal cortex dysfunction Is central to working memory storage and broad cognitive deficits in schizophrenia. J Neurosci 2018;38:8378-87.30104335 72. Barch DM, Csernansky JG. Abnormal parietal cortex activation during working memory in schizophrenia: verbal phonological coding disturbances versus domain-general executive dysfunction. Am J Psychiatry 2007;164:1090-8.17606661 73. Driesen NR, Leung HC, Calhoun VD et al. Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence. Biol Psychiatry 2008;64:1026-34.18823 880 74. Van Snellenberg JX, Torres IJ, Thornton AE. Functional neuroimaging of working memory in schizophrenia: task performance as a moderating variable. Neuropsychology 2006;20:497-510.16938013 75. Lee J, Folley BS, Gore J et al. Origins of spatial working memory deficits in schizophrenia: an event-related fMRI and near-infrared spectroscopy study. PLoS One 2008;3: e1760.18335036 76. Ragland JD, Laird AR, Ranganath C et al. Prefrontal activation deficits during episodic memory in schizophrenia. Am J Psychiatry 2009;166:863-74.19411370 77. Ragland JD, Ranganath C, Harms MP et al. Functional and neuroanatomic specificity of episodic memory dysfunction in schizophrenia: a functional magnetic resonance imaging study of the relational and item-specific encoding task. JAMA Psychiatry 2015; 72:909-16.26200928 78. Green MF, Glahn D, Engel SA et al. Regional brain activity associated with visual backward masking. J Cogn Neurosci 2005;17:13-23.15701236 79. Silverstein SM, Harms MP, Carter CS et al. Cortical contributions to impaired contour integration in schizophrenia. Neuropsychologia 2015;75:469-80.26160288 80. Glahn DC, Ragland JD, Abramoff A et al. Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. Hum Brain Mapp 2005;25:60-9.15846819 81. Karlsgodt KH, Sanz J, van Erp TG et al. Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia. Schizophr Res 2009;108:143-50.19196494 82. Haut KM, van Erp TG, Knowlton B et al. Contributions of feature binding during encoding and functional connectivity of the medial temporal lobe structures to episodic memory deficits across the prodromal and first-episode phases of schizophrenia. Clin Psychol Sci 2015;3:159-74.25750836 83. Taylor SF, Kang J, Brege IS et al. Meta-analysis of functional neuroimaging studies of emotion perception and experience in schizophrenia. Biol Psychiatry 2012;71:136-45.21993193 84. Li H, Chan RC, McAlonan GM et al. Facial emotion processing in schizophrenia: a meta-analysis of functional neuroimaging data. Schizophr Bull 2010;36:1029-39.19336391 85. Kronbichler L, Tschernegg M, Martin AI et al. Abnormal brain activation during theory of mind tasks in schizophrenia: a meta-analysis. Schizophr Bull 2017;43:1240-50.28575475 86. Decety J, Jackson PL. The functional architecture of human empathy. Behav Cogn Neurosci Rev 2004;3:71-100.15537986 87. Singer T, Lamm C. The social neuroscience of empathy. Ann NY Acad Sci 2009; 1156:81-96.19338504 88. Shamay-Tsoory SG. The neural bases for empathy. Neuroscientist 2011;17:18-24.21071616 89. Harvey PO, Zaki J, Lee J et al. Neural substrates of empathic accuracy in people with schizophrenia. Schizophr Bull 2013;39:617-28.22451493 90. Smith MJ, Schroeder MP, Abram SV et al. Alterations in brain activation during cognitive empathy are related to social functioning in schizophrenia. Schizophr Bull 2015; 41:211-22.24583906 91. Horan WP, Jimenez AM, Lee J et al. Pain empathy in schizophrenia: an fMRI study. Soc Cogn Affect Neurosci 2016;11:783-92.26746181 92. Vistoli D, Lavoie MA, Sutliff S et al. Functional MRI examination of empathy for pain in people with schizophrenia reveals abnormal activation related to cognitive perspective-taking but typical activation linked to affective sharing. J Psychiatry Neurosci 2017;42:262-72.28556774 93. Deserno L, Sterzer P, Wustenberg T et al. Reduced prefrontal-parietal effective connectivity and working memory deficits in schizophrenia. J Neurosci 2012;32:12-20.22219266 94. Quide Y, Morris RW, Shepherd AM et al. Task-related fronto-striatal functional connectivity during working memory performance in schizophrenia. Schizophr Res 2013;150:468-75.24016726 95. Eryilmaz H, Tanner AS, Ho NF et al. Disrupted working memory circuitry in schizophrenia: disentangling fMRI markers of core pathology vs other aspects of impaired performance. Neuropsychopharmacology 2016; 41:2411-20.27103065 96. Yoon JH, Minzenberg MJ, Raouf S et al. Impaired prefrontal-basal ganglia functional connectivity and substantia nigra hyperactivity in schizophrenia. Biol Psychiatry 2013;74:122-9.23290498 97. Hutcheson NL, Sreenivasan KR, Deshpande G et al. Effective connectivity during episodic memory retrieval in schizophrenia participants before and after antipsychotic medication. Hum Brain Mapp 2015;36:1442-57.25504918 98. Ray KL, Lesh TA, Howell AM et al. Functional network changes and cognitive control in schizophrenia. Neuroimage Clin 2017; 15:161-70.28529872 99. Cao H, Bertolino A, Walter H et al. Altered functional subnetwork during emotional face processing: a potential intermediate phenotype for schizophrenia. JAMA Psychiatry 2016;73:598-605.27145286 100. Bjorkquist OA, Olsen EK, Nelson BD et al. Altered amygdala-prefrontal connectivity during emotion perception in schizophrenia. Schizophr Res 2016;175:35-41.27083779 101. Bitsch F, Berger P, Nagels A et al. Impaired right temporoparietal junction-hippocampus connectivity in schizophrenia and its relevance for generating representations of other minds. Schizophr Bull (in press). 102. Braslow J. Mental ills and bodily cures: psychiatric treatment in the first half of the twentieth century. Berkeley: University of California Press, 1997. 103. Hegarty JD, Baldessarini RJ, Tohen M et al. One hundred years of schizophrenia: a meta-analysis of the outcome literature. Am J Psychiatry 1994;151:1409-16.8092334 104. Jaaskelainen E, Juola P, Hirvonen N et al. A systematic review and meta-analysis of recovery in schizophrenia. Schizophr Bull 2013;39:1296-306.23172003 105. Green M, Walker E. Susceptibility to backward masking in schizophrenic patients with positive and negative symptoms. Am J Psychiatry 1984;141:1273-5.6486266 106. Carrion RE, Goldberg TE, McLaughlin D et al. Impact of neurocognition on social and role functioning in individuals at clinical high risk for psychosis. Am J Psychiatry 2011;168:806-13.21536691 107. Horan WP, Green MF, DeGroot M et al. Social cognition in schizophrenia, Part 2: 12-month stability and prediction of functional outcome in first-episode patients. Schizophr Bull 2012;38:865-72.21382881 108. Gold JM, Goldberg RW, McNary SW et al. Cognitive correlates of job tenure among patients with severe mental illness. Am J Psychiatry 2002;159:1395-401.12153834 109. Robinson DG, Woerner MG, McMeniman M et al. Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder. Am J Psychiatry 2004;161:473-9.14992973 110. Stirling J, White C, Lewis S et al. Neurocognitive function and outcome in first-episode schizophrenia: a 10-year follow-up of an epidemiological cohort. Schizophr Res 2003;65:75-86.14630300 111. Friedman JI, Harvey PD, McGurk SR et al. Correlates of change in functional status of institutionalized geriatric schizophrenic patients: focus on medical comorbidity. Am J Psychiatry 2002;159:1388-94.12153833 112. Couture SM, Penn DL, Roberts DL. The functional significance of social cognition in schizophrenia: a review. Schizophr Bull 2006;32(Suppl. 1):S44-63.16916889 113. Fett AK, Viechtbauer W, Dominguez MD et al. The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci Biobehav Rev 2011;35:573-88.20620163 114. Brekke JS, Kay DD, Kee KS et al. Biosocial pathways to functional outcome in schizophrenia. Schizophr Res 2005;80:213-25. 16137859 115. Schmidt SJ, Mueller DR, Roder V. Social cognition as a mediator variable between neurocognition and functional outcome in schizophrenia: empirical review and new results by structural equation modeling. Schizophr Bull 2011;37(Suppl. 2):S41-54.21860046 116. Couture SM, Blanchard JJ, Bennett ME. Negative expectancy appraisals and defeatist performance beliefs and negative symptoms of schizophrenia. Psychiatry Res 2011;189:43-8.21704387 117. Grant PM, Beck AT. Defeatist beliefs as a mediator of cognitive impairment, negative symptoms, and functioning in schizophrenia. Schizophr Bull 2009;35:798-806.18308717 118. Bowie CR, Reichenberg A, Patterson TL et al. Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms. Am J Psychiatry 2006;163:418-25.16513862 119. Quinlan T, Roesch S, Granholm E. The role of dysfunctional attitudes in models of negative symptoms and functioning in schizophrenia. Schizophr Res 2014;157:182-9.24924405 120. Green MF, Hellemann G, Horan WP et al. From perception to functional outcome in schizophrenia: modeling the role of ability and motivation. Arch Gen Psychiatry 2012;69:1216-624.23026889 121. Thomas ML, Green MF, Hellemann G et al. Modeling deficits from early auditory information processing to psychosocial functioning in schizophrenia. JAMA Psychiatry 2017;74:37-46.27926742 122. Galderisi S, Rossi A, Rocca P et al. The influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophrenia. World Psychiatry 2014;13:275-87.25273301 123. Geyer MA, Tamminga CA. Measurement and treatment research to improve cognition in schizophrenia: neuropharmacological aspects. Psychopharmacology 2004;174:1-2. 124. Sinkeviciute I, Begemann M, Prikken M et al. Efficacy of different types of cognitive enhancers for patients with schizophrenia: a meta-analysis. NPJ Schizophr 2018;4:22. 30361502 125. Best MW, Bowie CR. A review of cognitive remediation approaches for schizophrenia: from top-down to bottom-up, brain training to psychotherapy. Expert Rev Neurother 2017;17:713-23.28511562 126. Wykes T, Huddy V, Cellard C et al. A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes. Am J Psychiatry 2011;168:472-85.21406461 127. Penades R, Gonzalez-Rodriguez A, Catalan R et al. Neuroimaging studies of cognitive remediation in schizophrenia: a systematic and critical review. World J Psychiatry 2017;7:34-43.28401047 128. Prikken M, Konings MJ, Lei WU et al. The efficacy of computerized cognitive drill and practice training for patients with a schizophrenia-spectrum disorder: a meta-analysis. Schizophr Res 2019;204:368-74.30097 278 129. Harvey PD, Sand M. Pharmacological augmentation of psychosocial and remediation training efforts in schizophrenia. Front Psychiatry 2017;8:177.28993740 130. Firth J, Stubbs B, Rosenbaum S et al. Aerobic exercise improves cognitive functioning in people with schizophrenia: a systematic review and meta-analysis. Schizophr Bull 2017;43:546-56.27521348 131. Jahshan C, Rassovsky Y, Green MF. Enhancing neuroplasticity to augment cognitive remediation in schizophrenia. Front Psychiatry 2017;8:191.29021765 132. Gupta T, Kelley NJ, Pelletier-Baldelli A et al. Transcranial direct current stimulation, symptomatology, and cognition in psychosis: a qualitative review. Front Behav Neurosci 2018;12:94.29892215 133. Horan WP, Kern RS, Penn DL et al. Social cognition training for individuals with schizophrenia: emerging evidence. Am J Psychiatr Rehabil 2008;11:205-52. 134. Kurtz MM, Richardson CL. Social cognitive training for schizophrenia: a meta-analytic investigation of controlled research. Schi-zophr Bull 2012;38:1092-104.21525166 135. Nahum M, Fisher M, Loewy R et al. A novel, online social cognitive training program for young adults with schizophrenia: a pilot study. Schizophr Res Cogn 2014;1: e11-9.25267937 136. Kurtz MM, Gagen E, Rocha NBF et al. Comprehensive treatments for social cognitive deficits in schizophrenia: a critical review and effect-size analysis of controlled studies. Clin Psychol Rev 2016;43:80-9.26437567 137. Campos C, Santos S, Gagen E et al. Neuroplastic changes following social cognition training in schizophrenia: a systematic review. Neuropsychol Rev 2016;26:310-28.27541742 138. Horan WP, Green MF. Treatment of social cognition in schizophrenia: current status and future directions. Schizophr Res 2019;203:3-11.28712968 139. Ebert A, Brune M. Oxytocin and social cognition. Curr Top Behav Neurosci 2018; 35:375-88.29019100 140. Grace SA, Rossell SL, Heinrichs M et al. Oxytocin and brain activity in humans: a systematic review and coordinate-based meta-analysis of functional MRI studies. Psychoneuroendocrinology 2018;96:6-24.29879563 141. Kendrick KM, Guastella AJ, Becker B. Overview of human oxytocin research. Curr Top Behav Neurosci 2018;35:321-48. 28864976 142. Burkner PC, Williams DR, Simmons TC et al. Intranasal oxytocin may improve high-level social cognition in schizophrenia, but not social cognition or neurocognition in general: a multilevel Bayesian meta-analysis. Schizophr Bull 2017;43:1291-303. 28586471 143. Davis MC, Green MF, Lee J et al. Oxytocin-augmented social cognitive skills training in schizophrenia. Neuropsychopharmacology 2014;39:2070-7.24637803 144. Cacciotti-Saija C, Langdon R, Ward PB et al. A double-blind randomized controlled trial of oxytocin nasal spray and social cognition training for young people with early psychosis. Schizophr Bull 2015;41:483-93. 24962607 145. Rassovsky Y, Dunn W, Wynn J et al. The effect of transcranial direct current stimulation on social cognition in schizophrenia: a preliminary study. Schizophr Res 2015;165:171-4.25934168 146. Rassovsky Y, Dunn W, Wynn JK et al. Single transcranial direct current stimulation in schizophrenia: randomized, cross-over study of neurocognition, social cognition, ERPs, and side effects. PLoS One 2018; 13:e0197023.29734347 147. Wynn JK, Green MF, Hellemann G et al. A dose-finding study of oxytocin using neurophysiological measures of social processing. Neuropsychopharmacology 2019;44: 289-94.30082892 148. Cohen AS, Minor KS. Emotional experience in patients with schizophrenia revisited: meta-analysis of laboratory studies. Schizophr Bull 2010;36:143-50.18562345 149. Horan WP, Kring AM, Blanchard JJ. Anhedonia in schizophrenia: a review of assessment strategies. Schizophr Bull 2006;32: 259-73.16221997 150. Horan WP, Wynn JK, Kring AM et al. Electrophysiological correlates of emotional responding in schizophrenia. J Abnorm Psychol 2010;119:18-30.20141239 151. Kring AM, Barch DM. The motivation and pleasure dimension of negative symptoms: neural substrates and behavioral outputs. Eur Neuropsychopharmacol 2014;24:725-36.24461724 152. Strauss GP, Whearty KM, Frost KH et al. An affective neuroscience model of impaired approach motivation in schizophrenia. NSNebr Symp Motiv 2016;63:159-203. 153. Painter JM, Kring AM. Toward an understanding of anticipatory pleasure deficits in schizophrenia: memory, prospection, and emotion experience. J Abnorm Psychol 2016;125:442-52.26950753 154. Dieleman S, Roder CH. Emotional memory modulation in schizophrenia: an overview. Acta Psychiatr Scand 2013;127:183-94.23216101 155. Ermakova AO, Knolle F, Justicia A et al. Abnormal reward prediction-error signalling in antipsychotic naive individuals with first-episode psychosis or clinical risk for psychosis. Neuropsychopharmacology 2018;43:1691-9.29748629 156. Waltz JA, Xu Z, Brown EC et al. Motivational deficits in schizophrenia are associated with reduced differentiation between gain and loss-avoidance feedback in the striatum. Biol Psychiatry Cogn Neurosci Neuroimaging 2018;3:239-47.29486865 157. Reddy LF, Waltz JA, Green MF et al. Probabilistic reversal learning in schizophrenia: stability of deficits and potential causal mechanisms. Schizophr Bull 2016;42:942-51.26884546 158. Heerey EA, Matveeva TM, Gold JM. Imagining the future: degraded representations of future rewards and events in schizophrenia. J Abnorm Psychol 2011;120:483-9. 21171727 159. Green MF, Horan WP, Barch DM et al. Effort-based decision making: a novel approach for assessing motivation in schizophrenia. Schizophr Bull 2015;41:1035-44.26089350 160. Gard DE, Kring AM, Gard MG et al. Anhedonia in schizophrenia: distinctions between anticipatory and consummatory pleasure. Schizophr Res 2007;93:253-60. 17490858 161. Frost KH, Strauss GP. A review of anticipatory pleasure in schizophrenia. Curr Behav Neurosci Rep 2016;3:232-47.27980891 162. Cho YT, Lam NH, Starc M et al. Effects of reward on spatial working memory in schizophrenia. J Abnorm Psychol 2018;127:695-709.30335439 163. Chung YS, Barch D, Strube M. A meta-analysis of mentalizing impairments in adults with schizophrenia and autism spectrum disorder. Schizophr Bull 2014;40:602-16.23686020 164. Mann CL, Footer O, Chung YS et al. Spared and impaired aspects of motivated cognitive control in schizophrenia. J Abnorm Psychol 2013;122:745-55.23834064 165. Strauss GP, Kappenman ES, Culbreth AJ et al. Emotion regulation abnormalities in schizophrenia: cognitive change strategies fail to decrease the neural response to unpleasant stimuli. Schizophr Bull 2013; 39:872-83.23314192 166. Sullivan SK, Strauss GP. Electrophysiological evidence for detrimental impact of a reappraisal emotion regulation strategy on subsequent cognitive control in schizophrenia. J Abnorm Psychol 2017;126:679-93. 28691849 167. Horan WP, Hajcak G, Wynn JK et al. Impaired emotion regulation in schizophrenia: evidence from event-related potentials. Psychol Med 2013;43:2377-91.23360592 168. Anticevic A, Corlett PR. Cognition-emotion dysinteraction in schizophrenia. Front Psychol 2012;3:392.23091464 169. Eack SM, Wojtalik JA, Barb SM et al. Fronto-limbic brain dysfunction during the regulation of emotion in schizophrenia. PLoS One 2016;11:e0149297.26930284 170. Van Dam NT, Rando K, Potenza MN et al. Childhood maltreatment, altered limbic neurobiology, and substance use relapse severity via trauma-specific reductions in limbic gray matter volume. JAMA Psychiatry 2014;71:917-25.24920451 171. Tendolkar I, Martensson J, Kuhn S et al. Physical neglect during childhood alters white matter connectivity in healthy young males. Hum Brain Mapp 2018;39:1283-90.29250891 172. Lim L, Hart H, Mehta MA et al. Neural correlates of error processing in young people with a history of severe childhood abuse: an fMRI study. Am J Psychiatry 2015;172:892-900.25882324 173. Matheson SL, Shepherd AM, Pinchbeck RM et al. Childhood adversity in schizophrenia: a systematic meta-analysis. Psychol Med 2013;43:225-38.22716913 174. Varese F, Smeets F, Drukker M et al. Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophr Bull 2012;38:661-71. 22461484 175. Vargas T, Lam PH, Azis M et al. Childhood trauma and neurocognition in adults with psychotic disorders: a systematic review and meta-analysis. Schizophr Bull (in press). 176. Schalinski I, Teicher MH, Carolus AM et al. Defining the impact of childhood adversities on cognitive deficits in psychosis: an exploratory analysis. Schizophr Res 2018;192:351-6.28576548 177. Kilian S, Asmal L, Chiliza B et al. Childhood adversity and cognitive function in schizophrenia spectrum disorders and healthy controls: evidence for an association between neglect and social cognition. Psychol Med 2018;48:2186-93.29268811 178. Alameda L, Fournier M, Khadimallah I et al. Redox dysregulation as a link between childhood trauma and psychopathological and neurocognitive profile in patients with early psychosis. Proc Natl Acad Sci USA 2018;115:12495-500.30455310 179. Everaerd D, Klumpers F, Zwiers M et al. Childhood abuse and deprivation are associated with distinct sex-dependent differences in brain morphology. Neuropsychopharmacology 2016;41:1716-23.26576924 180. Kumsta R, Marzi SJ, Viana J et al. Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. Transl Psychiatry 2016;6:e830.27271856 181. Bentall RP. The illusion of reality: a review and integration of psychological research on hallucinations. Psychol Bull 1990;107:82-95.2404293 182. Bentall RP, Slade PD. Reality testing and auditory hallucinations: a signal detection analysis. Br J Clin Psychol 1985;24:159-69.4052663 183. Lysaker PH, Hamm JA, Hasson-Ohayon I et al. Promoting recovery from severe mental illness: implications from research on metacognition and metacognitive reflection and insight therapy. World J Psychiatry 2018;8:1-11.29568726 184. Moritz S, Lysaker PH. Metacognition – What did James H. Flavell really say and the implications for the conceptualization and design of metacognitive interventions. Schizophr Res 2018;201:20-6.29903 626 185. Sellers R, Varese F, Wells A et al. A meta-analysis of metacognitive beliefs as implicated in the self-regulatory executive function model in clinical psychosis. Schizophr Res 2017;179:75-84.27670237 186. Brune M, Drommelschmidt KA, Kruger-Ozgurdal S et al. Relationship between metacognitive beliefs and psychosocial performance in at-risk states of psychosis and patients with first psychotic episodes. Early Interv Psychiatry (in press). 187. Davies G, Greenwood K. A meta-analytic review of the relationship between neurocognition, metacognition and functional outcome in schizophrenia. J Ment Health 2018;31:1-11. 188. Luther L, Bonfils KA, Firmin RL et al. Metacognition is necessary for the emergence of motivation in people with schizophrenia spectrum disorders: a necessary condition analysis. J Nerv Ment Dis 2017; 205:960-6.29064949 189. Lysaker PH, Gumley A, Luedtke B et al. Social cognition and metacognition in schizophrenia: evidence of their independence and linkage with outcomes. Acta Psychiatr Scand 2013;127:239-47.22967227 190. Koren D, Seidman LJ, Goldsmith M et al. Real-world cognitive – and metacognitive – dysfunction in schizophrenia: a new approach for measuring (and remediating) more “right stuff”. Schizophr Bull 2006;32:310-26.16397202 191. Lysaker PH, Gagen E, Moritz S et al. Metacognitive approaches to the treatment of psychosis: a comparison of four approaches. Psychol Res Behav Manag 2018;11:341-51.30233262 192. Inchausti F, Garcia-Poveda NV, Ballesteros-Prados A et al. The effects of metacognition-oriented social skills training on psychosocial outcome in schizophrenia-spectrum disorders: a randomized controlled trial. Schizophr Bull 2018;44:1235-44.29267940 193. Reeder C, Huddy V, Cella M et al. A new generation computerised metacognitive cognitive remediation programme for schizophrenia (CIRCuiTS): a randomised controlled trial. Psychol Med (in press). 194. Andreou C, Balzan RP, Jelinek L et al. Metacognitive training and metacognitive therapy. A reply to Lora Capobianco and Adrian Wells. J Behav Ther Exp Psychiatry 2018;59:162-3.29395038 195. Capobianco L, Wells A. Metacognitive therapy or metacognitive training: what’s in a name? J Behav Ther Exp Psychiatry 2018;59:161.29279140 196. Mednick SA, Machon RA, Huttunen MO et al. Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry 1988;45:189-92.3337616 197. Byrne M, Agerbo E, Bennedsen B et al. Obstetric conditions and risk of first admission with schizophrenia: a Danish national register based study. Schizophr Res 2007; 97:51-9.17764905 198. Cullen AE, Holmes S, Pollak TA et al. Associations between non-neurological autoimmune disorders and psychosis: a meta-analysis. Biol Psychiatry 2019;85:35-48. 30122288 199. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014;511:421-7. 25056061 200. Dickerson F, Stallings C, Origoni A et al. Inflammatory markers in recent onset psychosis and chronic schizophrenia. Schizophr Bull 2016;42:134-41.26294704 201. van Kesteren CF, Gremmels H, de Witte LD et al. Immune involvement in the pathogenesis of schizophrenia: a meta-analysis on postmortem brain studies. Transl Psychiatry 2017;7:e1075.28350400 202. Dickerson F, Stallings C, Origoni A et al. C-reactive protein is associated with the severity of cognitive impairment but not of psychiatric symptoms in individuals with schizophrenia. Schizophr Res 2007;93:261-5. 17490859 203. Martinez-Cengotitabengoa M, Mac-Dowell KS, Leza JC et al. Cognitive impairment is related to oxidative stress and chemokine levels in first psychotic episodes. Schizophr Res 2012;137:66-72.22445462 204. Zhang XY, Tang W, Xiu MH et al. Interleukin 18 and cognitive impairment in first episode and drug naive schizophrenia versus healthy controls. Brain Behav Immun 2013;32:105-11.23499732 205. Miller BJ, Buckley PF, McEvoy JP. Inflammation, substance use, psychopathology, and cognition in phase 1 of the clinical antipsychotic trials of intervention effectiveness study. Schizophr Res 2018;195: 275-82.28843438 206. Johnsen E, Fathian F, Kroken RA et al. The serum level of C-reactive protein (CRP) is associated with cognitive performance in acute phase psychosis. BMC Psychiatry 2016;16:60.26973142 207. Huys QJM, Maia TV, Paulus MP. Computational psychiatry: from mechanistic insights to the development of new treatments. Biol Psychiatry Cogn Neurosci Neuroimaging 2016;1:382-5.29560868 208. Krystal JH, Murray JD, Chekroud AM et al. Computational psychiatry and the challenge of schizophrenia. Schizophr Bull 2017;43: 473-5.28338845 209. Huys QJM. Advancing clinical improvements for patients using the theory-driven and data-driven branches of computational psychiatry. JAMA Psychiatry 2018;75:225-6.29344604 210. Murray JD, Anticevic A, Gancsos M et al. Linking microcircuit dysfunction to cognitive impairment: effects of disinhibition associated with schizophrenia in a cortical working memory model. Cerebral Cortex 2014;24:859-72.23203979 211. Starc M, Murray JD, Santamauro N et al. Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition. Schizophr Res 2017;181:107-16.27745755 212. Silverstein SM, Demmin DL, Bednar JA. Computational modeling of contrast sensitivity and orientation tuning in first-episode and chronic schizophrenia. Comput Psychiatr 2017;1:102-31.30090855 213. Dowd EC, Frank MJ, Collins A. Probabilistic reinforcement learning in patients with schizophrenia: relationships to anhedonia and avolition. Biol Psychiatry Cogn Neurosci Neuroimaging 2016;1:460-73. 27833939 214. Sterzer P, Adams RA, Fletcher P et al. The predictive coding account of psychosis. Biol Psychiatry 2018;84:634-43.30007575 215. Thakkar KN, Diwadkar VA, Rolfs M. Oculomotor prediction: a window into the psychotic mind. Trends Cogn Sci 2017;21:344-56.28292639 216. Barnett I, Torous J, Staples P. Relapse prediction in schizophrenia through digital phenotyping: a pilot study. Neuropsychopharmaco-logy 2018;43:1660-6.29511 333 217. Torous J, Kiang MV, Lorme J et al. New tools for new research in psychiatry: a scalable and customizable platform to empower data driven smartphone research. JMIR Ment Health 2016;3:e16.27150677 218. Insel T. Digital phenotyping: a global tool for psychiatry. World Psychiatry 2018; 17:276-7.30192103 219. Friston KJ, Frith CD. Schizophrenia: a disconnection syndrome? Clin Neurosci 1995; 3:89-97.7583624 220. Hoffman RE, Dobscha SK. Cortical pruning and the development of schizophrenia: a computer model. Schizophr Bull 1989; 15:477-90.2814376 221. Bullmore E, Sporns O. The economy of brain network organization. Nat Rev Neurosci 2012;13:336-49.22498897 222. Van Essen DC, Smith SM, Barch DM et al. The WU-Minn Human Connectome Project: an overview. Neuroimage 2013;80:62-9.23684880 223. Fornito A, Bullmore E, Zalesky A. Opportunities and challenges for psychiatry in the connectomic era. Biol Psychiatry Cogn Neurosci Neuroimaging 2017;2:9-19. 29560890 224. Lo CY, Su TW, Huang CC et al. Randomization and resilience of brain functional networks as systems-level endophenotypes of schizophrenia. Proc Natl Acad Sci USA 2015;112:9123-8.26150519 225. Sporns O. Contributions and challenges for network models in cognitive neuroscience. Nat Neurosci 2014;17:652-60.24686784 226. Cuthbert BN, Insel TR. Toward new approaches to psychotic disorders: the NIMH Research Domain Criteria project. Schizophr Bull 2010;36:1061-2.20929969 227. Cuthbert BN. The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology. World Psychiatry 2014;13:28-35.24497240 228. Tamminga CA, Pearlson GD, Stan AD et al. Strategies for advancing disease definition using biomarkers and genetics: the Bipolar and Schizophrenia Network for Intermediate Phenotypes. Biol Psychiatry Cogn Neurosci Neuroimaging 2017;2:20-7.2956 0884 229. Clementz BA, Sweeney JA, Hamm JP et al. Identification of distinct psychosis biotypes using brain-based biomarkers. Am J Psychiatry 2016;173:373-84.26651391 230. Calkins ME, Dobie DJ, Cadenhead KS et al. The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration. Schizophr Bull 2007;33:33-48. 17035358 231. Braff DL, Freedman R, Schork NJ et al. Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull 2007;33:21-32.17088422 232. Gaebel W. Status of psychotic disorders in ICD-11. Schizophr Bull 2012;38:895-8. 22987845